The first part, Language Endangerment and Endangered Languages, deals with issues related to language endangerment and the problems linguists and other researchers encounter when documenting these languages, both in general terms and with an eye on the Andean/Amazonian situation.

The second part, Specific Studies: Languages and Cultures of the Andean-Amazonian Border Area, contains three sections. The first deals with topics that relate to the Maku peoples and languages of Brazil (Eastern Maku) and Colombia (Western Maku). The second section features papers that address anthropological and grammatical issues concerning the Nambikwara peoples and languages (Brazil). The third section discusses various other languages in the Andean / Amazonian border area.